FOXO4-DRI 10 mg research-grade lyophilized peptide powder in a glass vial. FOXO4-DRI is a D-retro-inverso peptide designed to disrupt the interaction between the transcription factor FOXO4 and p53, and is used in experimental models of senescent cells, cellular aging and tissue homeostasis.
Research Use Only: All products are intended exclusively for laboratory and scientific research. Not for human or veterinary use.
Purity
High-purity research grade
Form
Lyophilized peptide powder
Content
10 mg FOXO4-DRI per vial
Packaging
Glass vial with sterile closure
Storage
Store lyophilized at 2–8 °C (desiccated, protect from light)
Molecular formula
C129 H227 N41 O35
Molecular weight
≈ 2888.4 g·mol⁻¹
Sequence (D-retro-inverso)
H-[dR][dP][dP][dK][dG][dS][dR][dR][dA][dW][dN][dG][dS][dQ][dA][dY][dE][dL][dS][dQ][dA][dI][dE][dS][dA][dP][dE][dK][dR][dL][dT][dL]-NH2
In laboratory workflows, lyophilized research peptides are typically handled with suitable sterile diluents such as bacteriostatic water (BAC). For a compatible research-only solvent, see
Bacteriostatic water – 10 ml .
Research Overview
FOXO4-DRI is used in research as a tool peptide to probe FOXO4–p53 signaling in senescent cells. By disrupting this interaction, it enables experimental investigation of selective senescent-cell clearance, tissue homeostasis and cellular aging pathways in vitro and in vivo laboratory models.
Primary Research Areas
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FOXO4–p53 interaction & signaling: Experimental studies examining how FOXO4-DRI disrupts FOXO4–p53 binding and alters downstream apoptosis and stress-response pathways in senescent cells.
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Senolysis & cellular senescence models: In vitro and in vivo models evaluating selective targeting of senescent cells and effects on senescence markers, SASP factors and tissue microenvironments.
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Aging & tissue homeostasis research: Laboratory investigations into how modulation of senescent-cell burden impacts tissue regeneration, organ function and age-related decline in controlled experimental systems.
