SLU-PP-332 250 mcg – 60 capsules research-grade formulation providing 250 mcg SLU-PP-332 per capsule, in a glass bottle of 60 research capsules. SLU-PP-332 is a compound which is a potent but non-selective estrogen-related receptor (ERR) agonist, acting most strongly at ERRα with an EC50 of 98 nM. It was found to counteract metabolic syndrome in mice, suggesting a possible role for compounds from this class as medications for the treatment of obesity.
Research Use Only: All products are intended exclusively for laboratory and scientific research. Not for human or veterinary use.
Purity
High purity (third-party tested)
Content
250 mcg SLU-PP-332 per capsule
Total capsules
60 capsules per bottle
Packaging
Glass bottle with plastic lid
Storage
Store at room temperature, protect from light, keep desiccated
Molecular Formula
C16H16N2O3
Molecular Weight
~284.31 g·mol⁻¹
IUPAC Name
5-methoxy-2-(naphthalen-2-yl)-2,3-dihydroisoindol-1-one
Research Overview
SLU-PP-332 is a small-molecule agonist of estrogen-related receptors (ERRα / ERRγ), nuclear receptors that play a central role in regulating mitochondrial biogenesis, oxidative metabolism, and fatty-acid utilization. Unlike stimulants or classical thermogenic agents, SLU-PP-332 does not act on the central nervous system. Instead, it reprograms metabolic gene expression in muscle and other tissues toward a highly oxidative, endurance-adapted phenotype, similar to changes observed with consistent aerobic training.
Primary Research Areas
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Estrogen-Related Receptor (ERRα / ERRγ) activation:
Research models examining nuclear receptor–mediated transcriptional control of oxidative metabolism, mitochondrial gene expression, and muscle fiber programming.
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Mitochondrial biogenesis & function:
Studies focused on mitochondrial density, respiratory capacity, electron transport chain efficiency, and adaptations associated with enhanced oxidative phosphorylation.
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Metabolic pathways & substrate utilization:
Investigation into fatty acid oxidation, glucose–lipid fuel switching, metabolic flexibility, and energy efficiency in skeletal muscle and peripheral tissues.
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Exercise-mimetic & endurance-related models:
Experimental work evaluating endurance capacity, fatigue resistance, and transcriptional profiles that resemble adaptations typically induced by aerobic training.
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Cellular energy regulation (PGC-1α signaling):
Research exploring downstream coactivator pathways involved in mitochondrial programming, oxidative enzyme expression, and long-term metabolic adaptation.
