MK-677 (Ibutamoren) 25 mg – 60 capsules research-grade capsule formulation supplied in a sealed bottle. MK-677 (also known as Ibutamoren) is a non-peptidic growth hormone secretagogue studied in experimental models of growth hormone/IGF-1 axis modulation, body composition, bone and muscle metabolism and sleep-related neuroendocrine signaling.
Research Use Only: All products are intended exclusively for laboratory and scientific research. Not for human or veterinary use.
Purity
99%+ (HPLC, third-party tested)
Content
25 mg MK-677 (Ibutamoren) per capsule; 60 capsules per bottle
Packaging
Sealed capsule bottle with tamper-evident closure
Storage
Store at 2–25 °C in a dry place, protected from heat and direct sunlight.
Molecular formula
C27H36N4O5S (Ibutamoren mesylate)
Molecular weight
≈ 528.7 g·mol⁻¹
IUPAC name
2-Amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4'-piperidine]-1'-yl)-2-(naphthalen-1-yl)ethyl]propanamide (mesylate)
Research Overview
MK-677 (Ibutamoren) is a small-molecule, non-peptidic growth hormone secretagogue that acts as an agonist at the ghrelin receptor (GHSR1a). In experimental systems, it is used to probe regulation of the growth hormone/IGF-1 axis, energy balance, body composition, bone remodeling and sleep-related neuroendocrine signaling in both in vitro and in vivo research models.
Primary Research Areas
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Growth hormone / IGF-1 axis modulation: Used in preclinical models to study how ghrelin-receptor agonism influences pituitary growth hormone secretion, circulating IGF-1 and downstream anabolic signaling pathways.
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Body composition and energy balance: Investigated in experimental settings evaluating lean mass, fat mass, nutrient partitioning and metabolic rate under conditions of altered GH/IGF-1 signaling.
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Bone density and musculoskeletal research: Applied in models of bone remodeling and muscle catabolism to explore interactions between GH/IGF-1 signaling, bone mineralization and muscle protein turnover.
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Sleep architecture and neuroendocrine rhythms: Used to examine relationships between ghrelin-receptor activation, slow-wave sleep, circadian hormone release and neuroendocrine homeostasis in experimental systems.
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Appetite and feeding behavior: Employed as a tool compound in studies of appetite regulation, hunger signaling and reward-linked feeding behavior mediated through central ghrelin pathways.
