B7-33 10 mg research-grade lyophilized peptide powder in a glass vial. B7-33 is a synthetic single-chain analog of the B-chain of human Relaxin-2, engineered to selectively activate the Relaxin Family Peptide Receptor 1 (RXFP1) in experimental models of fibrosis, cardiometabolic function and vascular biology.
Research Use Only: All products are intended exclusively for laboratory and scientific research. Not for human or veterinary use.
Purity
High-purity research grade
Form
Lyophilized peptide powder
Content
10 mg B7-33 peptide per vial
Packaging
Glass vial with sterile closure
Storage
Store lyophilized at 2–8 °C (desiccated, protect from light)
Molecular formula
C169 H280 N52 O48 S
Molecular weight
~3788.4 g·mol⁻¹
Sequence
Arg-Val-Ser-Glu-Glu-Trp-Nle-Asp-Leu-Ser-Pro-Glu-Asp-Ala-Pro-Pro-Lys-Met-Ser-Leu-Leu-Lys-Phe-Ile-Arg-Lys-Lys-Gln-Ala-His-Val-Phe-Arg
In laboratory workflows, lyophilized research peptides are typically handled with suitable sterile diluents such as bacteriostatic water (BAC). For a compatible research-only solvent, see
Bacteriostatic water – 10 ml .
Research Overview
B7-33 is a functionally selective single-B-chain analog of human Relaxin-2 designed to preferentially signal through RXFP1. In experimental models, it is used to study RXFP1-mediated ERK signaling, extracellular matrix remodeling and organ protection pathways without activating insulin or IGF receptors. Research focuses on anti-fibrotic, cardioprotective and vasoprotective mechanisms in vitro and in vivo.
Primary Research Areas
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RXFP1 receptor signaling: Studies on biased agonism at RXFP1, including ERK1/2 activation and cAMP-independent signaling profiles in relaxin receptor–expressing cells.
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Anti-fibrotic & extracellular matrix research: Experimental fibrosis models evaluating modulation of collagen deposition, matrix metalloproteinases and tissue remodeling pathways.
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Cardiovascular & vascular models: In vitro and in vivo systems investigating vasodilation, endothelial function and cardioprotective signaling under stress conditions.
