What is KPV?

KPV is a short tripeptide fragment of the hormone alpha-MSH, known for its anti-inflammatory and immunomodulatory effects. Unlike the whole alpha-MSH molecule, it does not exhibit melanotropic effects, which makes it an interesting subject of research in the field of chronic inflammation and skin diseases.

How does KPV work?

KPV acts mainly by inhibiting NF-κB signaling pathways, thereby suppressing the synthesis of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6. Studies have shown that KPV can stabilize the intestinal barrier, reduce mucosal inflammation, and promote epithelial regeneration, especially in models of colitis and dermatitis.

Researched effects and interesting facts

• Inflammatory bowel disease: reducing IBD symptoms and restoring the intestinal barrier
• Dermatological conditions: protecting the skin from inflammation and irritation
• Antimicrobial effect: suppression of the growth of some pathogenic bacteria
• No pigmentary effects: does not affect melanin production
• Immunoregulation: reducing inflammation without suppressing immunity

Dosage in studies

• Dosage: 200 – 1000 mcg daily
• Form: subcutaneous or intramuscular
• Frequency: 1 to 2 times a day
• Duration: 1 to 4 weeks depending on the protocol

Possible side effects

• Local irritation or redness at the application site
• Rarely, fatigue or mild drowsiness
• No effect on pigmentation or hormonal balance

Resources

• Chen Y et al. (2018). KPV peptide suppresses intestinal inflammation in murine colitis models
• Luger TA. et al. (2010). Anti-inflammatory properties of alpha-MSH and related peptides
• Ichiyama T. et al. (2009). KPV tripeptide in inflammatory skin models