TB-500 Fragment 17-23 10 mg research-grade lyophilized peptide powder supplied in a glass vial. TB-500 Fragment (17-23) is a heptapeptide fragment derived from the active region of thymosin beta-4, corresponding to amino acids 17–23 (sequence LKKTETQ), and is studied in experimental models of tissue repair, actin cytoskeleton modulation, angiogenesis and inflammation control.
Research Use Only: All products are intended exclusively for laboratory and scientific research. Not for human or veterinary use.
Purity
High-purity research grade
Form
Lyophilized peptide powder
Content
10 mg TB-500 Fragment (17-23) per vial
Packaging
Glass vial with sterile closure
Storage
Store lyophilized at 2–8 °C (desiccated, protect from light)
Molecular formula
C36H66N10O13
Molecular weight
~846.97 g·mol⁻¹
Sequence
Leu-Lys-Lys-Thr-Glu-Thr-Gln (LKKTETQ)
In laboratory workflows, lyophilized research peptides are typically handled with suitable sterile diluents such as bacteriostatic water (BAC). For a compatible research-only solvent, see
Bacteriostatic water – 10 ml .
Research Overview
TB-500 Fragment (17-23) is a short thymosin beta-4–derived heptapeptide encompassing the LKKTETQ motif that has been identified as an active domain involved in actin binding and tissue-repair–related signaling. In in vitro and in vivo experimental systems, this fragment is used as a minimalist tool to study how truncated thymosin beta-4–derived sequences can influence cell motility, wound closure, angiogenesis and inflammatory mediator profiles in a more focused manner than the full-length parent protein.
Primary Research Areas
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Actin cytoskeleton and cell motility: used in models evaluating how thymosin beta-4–derived fragments modulate actin polymerization, cytoskeletal dynamics and directed cell migration in fibroblasts, endothelial cells and other motile cell types under controlled laboratory conditions.
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Wound-healing and tissue-repair models: applied in experimental wound-closure assays to investigate fibroblast migration, extracellular matrix deposition and re-epithelialization processes associated with soft-tissue repair and regeneration research.
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Angiogenesis and vascular remodeling: incorporated into in vitro and in vivo angiogenesis models to explore endothelial cell migration, tube formation and vascular network remodeling, as well as interactions with growth factors such as VEGF in repair-focused studies.
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Inflammatory mediator modulation: used as a probe in research on cytokine and chemokine profiles at sites of experimental injury, examining how thymosin beta-4 fragments can influence the balance between pro- and anti-inflammatory signaling during tissue remodeling.
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Neuroprotection and CNS injury models: evaluated in preclinical central nervous system models to study potential effects on glial and neuronal cell survival, axonal support and inflammatory control in the context of brain and spinal cord injury research.
