Peptide 5 (Connexin 43) 5 mg
research-grade
lyophilized peptide powder
supplied in a glass vial. Peptide 5, also known as
αCT1 (alpha Connexin carboxyl-terminal 1),
is a synthetic nonapeptide corresponding to the C-terminal sequence of Connexin 43 (Cx43) that is studied in experimental models of gap
junction modulation, tissue repair and cell–cell communication.
Research Use Only:
All products are intended exclusively for laboratory and scientific research. Not for human or veterinary use.
Purity
99%+ (HPLC, third-party tested)
Form
Lyophilized peptide powder
Content
5 mg Peptide 5 (αCT1) per vial
Packaging
Glass vial with sterile closure
Storage
Store lyophilized at 2–8 °C (desiccated, protect from light)
Molecular formula
C47H78N14O16
Molecular weight
~1099.2 g·mol⁻¹
Sequence
Arg-Pro-Arg-Pro-Asp-Asp-Leu-Glu-Ile
In laboratory workflows, lyophilized research peptides are typically handled with suitable sterile diluents such as bacteriostatic water (BAC).
For a compatible research-only solvent, see
Bacteriostatic water – 10 ml
.
Research Overview
Peptide 5 (αCT1) is a synthetic nonapeptide corresponding to the final nine amino acids of the Connexin 43 (Cx43) C-terminus. In experimental
in vitro and in vivo models it is used to investigate how targeted modulation of Cx43–ZO-1 interactions and gap junction organization can
influence intercellular communication, barrier integrity and tissue repair processes in diverse organs and tissues.
Primary Research Areas
-
Gap junction modulation:
used in studies examining how modulation of Connexin 43-containing gap junctions alters intercellular coupling, electrical conductance and
signaling in cardiac, epithelial and other tissue models.
-
Connexin 43 / ZO-1 interaction:
applied to probe interactions between the Cx43 C-terminus and scaffolding proteins such as Zonula occludens-1 (ZO-1), and how these complexes
regulate junctional organization and barrier properties.
-
Wound healing and tissue repair models:
investigated in skin, corneal and other injury models where altered gap junction communication and Cx43 distribution are linked to tissue
repair dynamics and structural recovery endpoints.
-
Cardiac protection and anti-arrhythmic research:
used in preclinical cardiac models exploring whether targeted manipulation of Cx43-containing gap junctions can influence conduction
heterogeneity, arrhythmia susceptibility and myocardial injury responses under controlled conditions.
-
Cell–cell communication in diverse tissues:
included in broader research on how connexin-based junctions coordinate cell behavior, growth and differentiation across epithelial,
endothelial and other cellular networks.
