PE22-28 5 mg
research-grade
lyophilized peptide powder
in a glass vial. PE22-28, also known as Spadin, is a synthetic heptapeptide
(Phe-Ser-Arg-Pro-Pro-Asn-Gly) derived from sortilin-processed Peptide E and studied
as a selective agonist of the TrkB receptor in neuroplasticity and mood-related
research models.
Research Use Only:
All products are intended exclusively for laboratory and scientific research. Not for human or veterinary use.
Purity
High-purity research grade
Form
Lyophilized peptide powder
Content
5 mg PE22-28 (Spadin) per vial
Packaging
Glass vial with sterile closure
Storage
Store lyophilized at 2–8 °C (desiccated, protect from light)
Molecular formula
C34
H51
N11
O9
Molecular weight
~761.8 g·mol⁻¹
Sequence
Phe-Ser-Arg-Pro-Pro-Asn-Gly
In laboratory workflows, lyophilized research peptides are typically handled with suitable sterile diluents such as bacteriostatic water (BAC).
For a compatible research-only solvent, see
Bacteriostatic water – 10 ml
.
Research Overview
PE22-28 (Spadin) is a short neuroactive heptapeptide derived from Peptide E, a cleavage
product of the sortilin–propeptide pathway. In experimental neuroscience models it is used
to investigate selective TrkB receptor activation, BDNF-mimetic signalling, hippocampal
neurogenesis and modulation of neuronal survival pathways in vitro and in vivo, without
implying any therapeutic application.
Primary Research Areas
-
TrkB receptor & BDNF mimetic signalling:
Experimental models using PE22-28 as a selective TrkB agonist to probe BDNF-related
signalling cascades and downstream kinase activation.
-
Neurogenesis & synaptic plasticity:
In vitro and in vivo studies examining hippocampal neurogenesis, synaptic density
markers and plasticity-associated proteins under PE22-28 exposure.
-
Mood & stress-related models:
Laboratory models of depression, anxiety and stress resilience evaluating how TREK-1 /
TrkB pathway modulation influences behavioural and molecular readouts.
