Orexin B 5 mg research-grade lyophilized peptide powder in a glass vial. This hypothalamic neuropeptide (also known as Hypocretin-2, Hcrt-2) is studied in experimental models of wakefulness, sleep–wake regulation, appetite control, energy balance and reward-related signaling.
Research Use Only: All products are intended exclusively for laboratory and scientific research. Not for human or veterinary use.
Purity
99%+ (HPLC, third-party tested)
Form
Lyophilized peptide powder
Content
5 mg Orexin B per vial
Packaging
Glass vial with sterile closure
Storage
Store lyophilized at 2–8 °C in a dry place, protected from light.
Molecular formula
C123H212N44O35S
Molecular weight
≈ 2,899.3 g·mol⁻¹
Sequence (human)
Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2
In laboratory workflows, lyophilized research peptides are typically handled with suitable sterile diluents such as bacteriostatic water (BAC). For a compatible research-only solvent, see
Bacteriostatic water – 10 ml .
Research Overview
Orexin B is an endogenous hypothalamic neuropeptide derived from the prepro-orexin precursor and is one of the two orexin/hypocretin ligands alongside Orexin A. In experimental systems, Orexin B acts predominantly at the Orexin Receptor 2 (OX2R), where it serves as a potent agonist used to probe sleep–wake circuitry, arousal states, feeding behavior, energy homeostasis and reward-related pathways in vitro and in vivo research models.
Primary Research Areas
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Sleep–wake regulation and narcolepsy models: Used in laboratory studies investigating hypothalamic circuits that stabilize wakefulness, model narcolepsy-like phenotypes and dissect orexinergic contributions to sleep–wake transitions via OX2R signaling.
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Arousal, vigilance and stress-related arousal: Applied in experimental preparations to examine how orexinergic input modulates neuronal excitability, cortical activation and behavioral arousal under baseline and stress-related conditions.
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Appetite and energy homeostasis: Studied in preclinical feeding and metabolic models to explore the role of Orexin B in food intake, energy expenditure and integration of metabolic cues at the level of the hypothalamus.
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Reward and motivation circuitry: Employed to investigate orexinergic modulation of mesolimbic and mesocortical pathways, including reward-driven behaviors and motivational salience in rodent and in vitro systems.
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Synaptic transmission and neuronal plasticity: Used in electrophysiological and imaging studies to characterize how Orexin B influences glutamatergic signaling, neuronal firing patterns and plasticity in defined brain regions.
