Melanotan 1 10 mg
research-grade
lyophilized peptide powder
supplied in a glass vial. Also known as Afamelanotide or MT-1, this synthetic peptide is an analog of the endogenous
alpha-Melanocyte-Stimulating Hormone (α-MSH), studied in experimental models of melanocortin receptor signaling,
pigmentation biology and photobiology.
Research Use Only:
All products are intended exclusively for laboratory and scientific research. Not for human or veterinary use.
Purity
High-purity research grade
Form
Lyophilized peptide powder
Content
10 mg Melanotan 1 per vial
Packaging
Glass vial with sterile closure
Storage
Store lyophilized at 2–8 °C (desiccated, protect from light)
Molecular formula
C78H111N21O19
Molecular weight
~1646.8 g·mol⁻¹
Sequence
Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
In laboratory workflows, lyophilized research peptides are typically handled with suitable sterile diluents such as bacteriostatic water (BAC).
For a compatible research-only solvent, see
Bacteriostatic water – 10 ml
.
Research Overview
Melanotan 1 (Afamelanotide) is a synthetic peptide analog of the naturally occurring α-melanocyte-stimulating hormone (α-MSH),
incorporating the [Nle4, D-Phe7] substitutions to enhance stability and receptor affinity in experimental systems. In in vitro and
in vivo research models, Melanotan 1 is used to probe melanocortin 1 receptor (MC1R) agonism, melanocyte signaling pathways,
melanin synthesis and photobiological responses to ultraviolet (UV) exposure under controlled laboratory conditions.
Primary Research Areas
-
Melanocortin receptor signaling:
used in studies of MC1R activation, downstream cAMP/PKA pathways and transcriptional control of pigment-related genes in
melanocytic cell models and other systems expressing melanocortin receptors.
-
Melanogenesis and pigment biology:
applied to investigate eumelanin synthesis, melanosome biogenesis, pigment distribution and regulatory feedback loops in
pigmentation biology research.
-
Photobiology and UV-response models:
incorporated into experimental designs exploring cellular responses to UV radiation, including photobiological stress pathways
and melanin-mediated modulation of UV-induced damage in vitro and in vivo models.
-
Erythropoietic protoporphyria (EPP) models:
used as a tool compound in research on porphyrin-related photosensitivity, exploring how melanocortin-based modulation of
pigmentation affects experimental EPP models.
-
DNA damage and repair after UV exposure:
utilized in studies of UV-induced DNA lesions, repair kinetics and associated oxidative stress markers in relation to increased
melanin levels and melanocortin signaling.
