Matrixyl (Palmitoyl Pentapeptide-4) 10 mg research-grade lyophilized peptide powder supplied in a glass vial. This synthetic lipopeptide, commonly known by the trade name Matrixyl, consists of the pentapeptide sequence Lys-Thr-Thr-Lys-Ser (KTTKS) covalently linked to palmitic acid (Pal-KTTKS) and is studied in cosmetic science and extracellular matrix research models.
Research Use Only: All products are intended exclusively for laboratory and scientific research. Not for human or veterinary use.
Purity
High-purity research grade
Form
Lyophilized peptide powder
Content
10 mg Matrixyl (Palmitoyl Pentapeptide-4, Pal-KTTKS) per vial
Packaging
Glass vial with sterile closure
Storage
Store lyophilized at 2–8 °C (desiccated, protect from light)
Molecular formula
C39H75N7O10
Molecular weight
~802.05 g·mol⁻¹
Sequence
Palmitoyl-Lys-Thr-Thr-Lys-Ser-OH (Pal-KTTKS)
In laboratory workflows, lyophilized research peptides are typically handled with suitable sterile diluents such as bacteriostatic water (BAC). For a compatible research-only solvent, see
Bacteriostatic water – 10 ml .
Research Overview
Matrixyl (Palmitoyl Pentapeptide-4, Pal-KTTKS) is a synthetic matrikine-type lipopeptide combining a collagen-derived pentapeptide fragment (KTTKS) with a C16 palmitoyl chain to improve stability and interaction with lipid environments. In experimental in vitro and in vivo cosmetic science models it is used to investigate signaling processes in dermal fibroblasts, including the regulation of extracellular matrix protein synthesis and cell-matrix communication relevant to skin structure and appearance.
Primary Research Areas
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Collagen synthesis in dermal fibroblasts: used in models examining stimulation of type I, III and IV collagen production and associated changes in extracellular matrix architecture under controlled laboratory conditions.
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Extracellular matrix remodeling: applied in studies of elastin, fibronectin and glycosaminoglycan (e.g. hyaluronic acid) synthesis, matrix turnover and tissue remodeling pathways in skin-equivalent systems.
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Skin aging and wrinkle biology models: incorporated into in vitro and ex vivo setups that simulate photoaging or chronological aging to evaluate ECM-related markers linked to wrinkle formation and loss of dermal firmness.
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Wound healing and repair mechanisms: used as a tool compound in research on fibroblast migration, contractility and matrix deposition in models of cutaneous repair and tissue regeneration.
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Matrikine signaling pathways: utilized to investigate peptide-mediated activation of cell-surface receptors and downstream gene expression programs involved in extracellular matrix renewal and dermal homeostasis.
