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Tesofensine is an investigational drug originally studied in Parkinson's and Alzheimer's disease. It has shown potent anorectic effects in studies and has become a subject of research in weight loss and metabolic disorders.
Active ingredient content
500 mcg in 1 capsule
Packaging
60 capsules in a protective container
Storage
Up to 25 °C, in a dry and dark place
Molecular formula
C17H23Cl2NO
Molecular weight
328.28 g mol⁻¹
IUPAC name
(3,4-Dichloro-phenyl)-(2-dimethylaminoethyl)methyl ether
Other names
Tesofensinum, NS2330
In laboratory conditions, tesofensine is mainly studied for:
- reduced appetite and calorie intake,
- modulation of dopamine, noradrenergic and serotonergic pathways,
- increased energy expenditure and activity,
- improving mood and cognitive functions,
- research into neurodegenerative disorders.
This content is for educational purposes only. It is not a recommendation for human use. The substance is intended for laboratory research only.
What is Tesofensine?
Tesofensine is a synthetic substance that inhibits the reuptake of three neurotransmitters: dopamine, noradrenaline, and serotonin. This triple inhibition leads to increased signaling in the central nervous system, resulting in decreased appetite, increased alertness, and increased energy. It was originally studied for neurodegenerative diseases, but later attracted interest in the areas of obesity and metabolic disorders.
How does Tesofensine work?
The mechanism of action is to inhibit the reuptake of neurotransmitters, thereby increasing their availability in the synaptic cleft. This leads to:
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Dopamine: Increases motivation, reduces compulsive eating.
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Noradrenaline: Increases alertness, sympathetic activation, and energy expenditure.
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Serotonin: Mood stabilization, satiety regulation.
Effects studied
- Body weight loss in the range of 10–12% in 24 weeks in some clinical phases.
- Reducing appetite and shortening the time between feelings of fullness.
- Improvement in mood, cognition, and subjective energy.
- Observed synergy with caffeine and stimulants.
Dosage in studies
The data comes exclusively from laboratory research. It is not a recommendation for real-world use.
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Dose: 0.25–1 mg daily
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Administration form: oral (capsules)
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Frequency: 1x daily, morning
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Duration: 4–24 weeks depending on protocol
Possible side effects
- Dry mouth
- Insomnia (especially with evening dosing)
- Increased pulse or blood pressure (at high doses)
- Nervousness, tremors
Resources
- Larsen, TM et al. (2008). Effect of tesofensine on weight loss in obese patients: a randomised, double-blind, placebo-controlled trial. Lancet.
- ClinicalTrials.gov - NCT00394667
- Mortensen, OH et al. (2009). Neurochemical profile of tesofensine , Journal of Neurochemistry
This article is for educational purposes only and does not constitute any recommendation for use. All information is based on published studies.
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