Tesamorelin is a synthetic peptide from the class of GHRH analogues, best known for its ability to stimulate the release of growth hormone (GH) through the activation of GHRH receptors in the pituitary gland.
Active ingredient content
10 mg
Packaging
Glass bottle with rubber stopper
Storage
2–8°C, protect from light
Molecular formula
C221H366N72O67S
Molecular weight
5135.89 g mol⁻¹
IUPAC name
TBC (too long for compact display)
Other names
GRF 1-44 tetrasubstituted, Egrifta
In laboratory studies, Tesamorelin is associated with research in areas such as:
- stimulation of growth hormone secretion,
- reduction of visceral fat,
- improvement of lipid profile and insulin sensitivity,
- protection of muscle mass during caloric restriction,
- studying neuroprotective and cognitive effects.
This content is for educational purposes only. It is not a recommendation for human use. The substance is intended for laboratory research only.
What is Tesamorelin?
Tesamorelin is a synthetic peptide derived from natural GHRH (growth hormone releasing hormone). It consists of 44 amino acids, and compared to native GHRH, it has higher stability and a prolonged plasma half-life. Tesamorelin selectively stimulates GHRH receptors in the pituitary gland, thereby promoting the release of endogenous growth hormone (GH) without exogenous supplementation of the hormone itself.
It is the subject of research for its effects on metabolism, redistribution of fat stores, and neuroprotection, especially in relation to lipodystrophy or aging.
How does Tesamorelin work?
The mechanism of action of Tesamorelin is based on the activation of GHRH receptors on the cells of the anterior pituitary gland. The result is increased secretion of growth hormone (GH), which in turn stimulates the production of IGF-1 in the liver. This process mimics natural hormonal pathways, while maintaining physiological feedback regulation.
Unlike exogenous growth hormone, Tesamorelin supports natural GH pulses and does not suppress endogenous production, making it a subject of interest in research focused on less invasive ways of modulating anabolic and metabolic processes.
Researched effects and interesting facts
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Visceral fat reduction: Studies have shown a decrease in fat stores in the abdominal area without a negative impact on subcutaneous fat or muscle.
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IGF-1 Increase: Significant increase in IGF-1 levels, leading to anabolic and regenerative benefits.
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Neuroprotection: Research suggests positive effects on cognitive function and brain protection against aging.
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Improvement of lipid profile: Observed decrease in triglyceride and total cholesterol levels.
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Insulin sensitivity: Better glycemic control and lower insulin resistance have been reported in some models.
Dosage in studies
The values listed are derived solely from research studies and are not intended for real-world use outside of a laboratory environment.
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Dosage: 1 – 2 mg daily
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Form: subcutaneous (sc)
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Frequency: 1x daily, evening
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Duration: 12 – 26 weeks depending on the study
Possible side effects (subcutaneous form)
- Redness or irritation at the injection site
- Mild water retention
- Joint pain or stiffness
- Rarely hypoglycemia or rashes
Resources
- Stanley, TL et al. (2011). Effects of tesamorelin on visceral fat
- Falutz, J. et al. (2007). Metabolic effects of tesamorelin in HIV-associated lipodystrophy
- Hayashi, AA et al. (2015). GHRH analogues and neurodegeneration
- Grinspoon, SK et al. (2010). Tesamorelin and cardiovascular risk markers
This article is for informational purposes only. It does not constitute a recommendation or solicitation for use. The information provided is a summary of existing scientific literature and is for educational purposes only.
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