Semax is a synthetic peptide derivative of adrenocorticotropic hormone (ACTH) that was developed in Russia for research purposes related to neuroprotection, cognitive functions, and adaptogenic properties. It is characterized by high stability and good permeability through the blood-brain barrier.
Contents
40 mg of active ingredient
Concentration (test)
39.15 mg ± 0.05 mg
Storage
In a dry, dark place, at a temperature of up to 8 °C
Molecular formula
C37H51N9O10S
Molecular weight
831.93 g mol⁻¹
Other names
Met-Glu-His-Phe-Pro-Gly-Pro
In laboratory studies, Semax has been linked to research in areas such as:
- neuroprotection and prevention of neurodegeneration,
- supporting memory, learning and attention,
- reducing anxiety and stress reactions,
- regeneration after ischemic events,
- modulation of neurotrophic factors.
This content is for educational purposes only. It is not a recommendation for human use. The substance is intended for laboratory research only.
What is Semax?
Semax is a synthetic neuropeptide consisting of the ACTH (4-10) fragment, supplemented with modifications to increase its stability. Originally developed at the Russian Academy of Sciences, it has become the subject of research for its potential cognitive, neuroprotective and adaptogenic effects. In studies, it has shown the ability to influence neurotrophin levels (especially BDNF), which is associated with neuronal regeneration and improved synaptic plasticity.
How does Semax work?
The mechanism of action of Semax is not fully understood, but research suggests that it may influence the expression of neurotrophic factors (e.g. BDNF), antioxidants and anti-inflammatory molecules. In addition, its interaction with dopamine and serotonin pathways has been observed, which may affect mood and attention. In experimental models, it also reduces oxidative stress and helps restore brain structures after ischemic damage.
Effects studied
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Neuroprotection: Significant effects in protecting brain tissue from damage (hypoxia, trauma).
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Cognitive support: Improving memory, learning, attention, and the ability to concentrate.
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Antidepressant potential: In some models, reducing anxiety and increasing adaptation to stress.
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BDNF modulation: Increasing the expression of the neurotrophin BDNF, important for brain plasticity.
Dosage in studies
The values listed are derived solely from research studies and are not intended for real-world use outside of a laboratory environment.
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Dose: 200 – 600 μg daily
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Form: subcutaneous
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Frequency: 1–2 times a day
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Duration: 7 – 14 days according to experimental protocol
Possible side effects
- Mild irritation of the nasal mucosa upon intranasal administration
- Rarely insomnia or mild nervousness
- With subcutaneous administration, pain at the injection site is possible.
Resources
- Ashmarin, IP et al. (2005). Neuroprotective effects of Semax in models of hypoxia and ischemia
- Andreeva, LA et al. (2012). Semax-induced modulation of BDNF expression in cerebral cortex
- Kolomin, CG et al. (2018). Semax and its analogues in neuropharmacology
This article is for informational purposes only. It does not constitute a recommendation or solicitation for use. The information provided is a summary of existing scientific literature and is for educational purposes only.
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