RU-58841 is a non-selective non-steroidal antiandrogen studied in experimental models for its effects on androgen receptors in skin tissue, hair follicles, and sebaceous glands. It is most commonly used in the form of a solution for external application.
Form
Solution in carrier oil (dropper bottle)
Contents
Not specified (mg/ml depending on batch)
Concentration (test)
Unspecified
Packaging
Glass dropper bottle with oil solution
Storage
2–8°C, protect from light
Molecular formula
C17H18F3N3O3
Molecular weight
369.34 g mol⁻¹
IUPAC name
4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile
Other names
PSK-3841, HMR-3841, RU58841
In laboratory studies, RU-58841 has been linked to research in areas such as:
- blockade of androgen receptors in skin tissues,
- study of the effect on hair follicles and the hair cycle,
- sebaceous glands and skin homeostasis,
- androgenetic alopecia models,
- synergy with other topical agents.
This content is for educational purposes only. It is not a recommendation for human use. The substance is intended for laboratory research only.
What is RU-58841
RU-58841 is a synthetic nonsteroidal antiandrogen compound. It is being studied in models primarily for its ability to bind to androgen receptors in skin and hair tissue, thereby potentially preventing the action of androgens on these receptors.
It differs from systemic antiandrogens in that it is used in laboratory experiments predominantly in topical (local) form, thereby investigating its selective effect on surface tissues.
How RU-58841 works
The mechanism of action is through competitive binding to androgen receptors in hair follicle and skin cells, which can reduce transcriptional activity associated with androgen signals.
In experiments, its local activity and short half-life are mainly monitored, which minimizes systemic effects and allows targeting of target tissues during external use.
Researched effects and interesting facts
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Androgen receptors: Blockade of androgen receptors in the skin and hair follicles.
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Hair cycle: Observed effect on anagen phase prolongation in models.
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Sebaceous glands: Potential effect on reducing sebaceous gland activity.
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Selectivity: Topical form limits systemic effects.
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Combinations: Being tested in conjunction with other experimental topical agents.
Dosage in studies
The values listed are derived solely from research studies and are not intended for real-world use outside of a laboratory environment.
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Dose: 5 – 50 mg daily (locally applied amount)
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Form: topical solution (oil carrier)
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Frequency: 1x daily according to protocol
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Duration: 4 – 12 weeks in experimental models
The dosage information is only a summary of data from experimental studies. It does not constitute instructions for use or a recommendation.
Possible side effects
- Skin irritation, redness, or itching
- Dryness or flaking of the skin
- Local burning or temporary discomfort after application
Resources
- PubChem: RU-58841 (CID: 6918809)
- Preclinical studies of antiandrogens in topical models
- Publications on androgen receptors and the hair cycle
- Experimental work on the local application of antiandrogens
This article is for informational purposes only. It does not constitute a recommendation or solicitation for use. The information provided is a summary of existing scientific literature and is for educational purposes only.
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