Pentosan Polysulfate (PPS) is a semi-synthetic sulfated polysaccharide that has been associated in laboratory research with modulation of inflammatory and coagulation pathways, interactions with the extracellular matrix, tissue permeability, and protective mechanisms of mucosal surfaces.
Contents
250 mg/ml – 20 ml (sterile solution)
Concentration (test)
Unspecified
Packaging
20 ml glass bottle with sterile cap
Storage
Store in a dry place, at room temperature, away from light.
Molecular formula
Unspecified (polymer blend)
Molecular weight
Unspecified (polydisperse)
Other names
Pentosan polysulfate sodium (PPS), PPS
In laboratory studies, Pentosan Polysulfate is associated with research in areas such as:
- modulation of coagulation and interaction with heparinoid pathways,
- anti-inflammatory mechanisms and cytokine profiles,
- protection of mucosal barriers and glycosaminoglycan layers,
- binding to ECM components and tissue permeability,
- microcirculation, viscoelasticity and rheological properties of blood.
This content is for educational purposes only. It is not a recommendation for human use. The substance is intended for laboratory research only.
What is Pentosan Polysulfate?
Pentosan Polysulfate is a sulfated polysaccharide with structural affinity to heparinoids. In experimental systems, it is associated with interactions at the extracellular matrix level, with cell surfaces and with blood plasma proteins, which may influence inflammation, coagulation and tissue barrier properties.
The research focuses on the physicochemical properties of PPS, its binding behavior, and effects on the local tissue environment under stress conditions.
How Pentosan Polysulfate works
In model conditions, the electrostatic interaction of PPS with proteins and glycosaminoglycans, which can alter the availability of mediators, surface charges and local microconditions, is monitored. The impact on cytokine networks, coagulation cascades and binding to ECM components is evaluated.
At the tissue level, the impact on microcirculation, viscosity and permeability, as well as the support of protective layers on mucosal surfaces, is analyzed.
Researched effects and interesting facts
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Anti-inflammatory modulation: Changes in cytokine and chemokine profiles in stress models.
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Heparinoid properties: Observed interactions with coagulation proteins and antithrombotic pathways.
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Barrier protection: Evidence for effects on glycosaminoglycan layers and mucosal integrity.
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ECM interactions: Binding to collagen/elastin and influencing local tissue conditions.
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Microcirculation and rheology: Viscosity and flow parameters in experimental models.
Dosage in studies
The values listed are derived solely from research studies and are not intended for real-world use outside of a laboratory environment.
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Dose: Not specified (mg/kg and mg/day are given according to the model and objective of the study)
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Form: injectable (solution; preferred sc or im)
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Frequency: 1–3 times a week to 1 time a day according to the protocol
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Duration: approximately 2 - 12 weeks depending on the monitored parameters
The dosage information is a summary of experimental data and does not constitute instructions for use or a recommendation.
Possible side effects
- Changes in coagulation parameters and risk of bleeding (depending on the protocol)
- Local reactions at the injection site (erythema, tenderness)
- Gastrointestinal symptoms or headaches in some models
Resources
- Review papers on heparinoid polysaccharides and coagulation pathways
- Studies on the anti-inflammatory and barrier effects of PPS in tissue models
- Publications on PPS interactions with ECM and microcirculation
- Methodological protocols for experimental evaluation of rheology and permeability
This article is for informational purposes only. It does not constitute a recommendation or solicitation for use. The information provided is a summary of existing scientific literature and is for educational purposes only.
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