MOTS-c is a mitochondrially derived peptide that is produced by transcription of a short open reading frame (sORF) in mitochondrial DNA. It is currently the subject of intense research, particularly for its ability to influence metabolism, insulin sensitivity, and cellular stress responses.
Active ingredient content
10 mg
Concentration (test)
15.91 mg
Packaging
Glass bottle with sterile cap
Storage
2–8 °C, away from light
Molecular formula
C49H75N15O10
Molecular weight
1026.2 g mol⁻¹
IUPAC name
MOTS-c (peptide)
Other names
MOTS-c peptide, mitochondrial-derived peptide
In laboratory studies, MOTS-c is associated with research in areas such as:
- metabolic balance and increased insulin sensitivity,
- supporting glucose and fat metabolism,
- protection against oxidative stress,
- improving performance and endurance,
- neuroprotective effects and mitochondrial support.
This content is for educational purposes only. It is not a recommendation for human use. The substance is intended for laboratory research only.
What is MOTS-c?
MOTS-c is a short mitochondrial peptide consisting of 16 amino acids, which is encoded by mitochondrial DNA. This peptide has been investigated in recent years as a potential regulator of metabolism, cellular protection and signaling between mitochondria and the nucleus. Due to its ability to influence AMPK pathways and metabolic homeostasis, it is considered a promising subject of research in areas such as obesity, insulin resistance and mitochondrial dysfunction.
How MOTS-c works
MOTS-c acts through activation of AMPK, leading to increased fatty acid oxidation, decreased lipid synthesis, and improved insulin sensitivity. It also inhibits the mTOR signaling pathway, increasing cellular resistance to stress. In models of metabolic syndrome, it has been shown to have a positive effect on lowering blood glucose, reducing fat mass, and improving physical performance.
Effects studied
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Improving insulin sensitivity: AMPK activation promotes glucose transport into cells without the need for insulin.
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Reduction of fat mass: Promoting fat oxidation and inhibiting its synthesis.
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Mitochondrial protection: Improving mitochondrial function and preventing their damage.
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Endurance and physical performance: Increasing aerobic capacity in preclinical models.
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Resistance to cellular stress: Impact on antioxidant and cytoprotective pathways.
Dosage in studies
The values listed are derived solely from research studies and are not intended for real-world use outside of a laboratory environment.
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Dosage: 5 – 15 mg daily
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Administration form: intraperitoneal or subcutaneous injection (in animal models)
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Frequency: 1× daily
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Duration: 7 – 30 days depending on the research
Possible side effects
- Transient fatigue or decreased energy after administration
- Irritation or tenderness at the injection site
- Glucose level fluctuations (high doses)
Resources
- Lee, C. et al. (2015). The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance
- Kim, KH et al. (2018). Mitochondrial peptides as novel regulators of metabolism
- ClinicalTrials.gov – experimental use of MOTS-c in metabolic and mitochondrial research
This article is for informational purposes only. It does not constitute a recommendation or solicitation for use. The information provided is a summary of existing scientific literature and is for educational purposes only.
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