Ipamorelin is a synthetic peptide being studied as a selective growth hormone stimulator. Scientifically significant, it stimulates the pituitary gland without increasing cortisol or prolactin levels, making it a subject of interest in preclinical research focused on growth, regeneration, and hormonal balance.
Concentration (test)
5.98 mg
Packaging
Glass bottle with cap
Storage
2–8 °C, away from light
Molecular formula
C38H49N9O5
Molecular weight
711.85 g mol⁻¹
Other names
Ipamorelin acetate
In laboratory studies, Ipamorelin has been linked to research in areas such as:
- stimulation of growth hormone secretion without affecting cortisol,
- preservation of muscle mass during catabolism,
- regeneration and restoration of damaged tissues,
- investigating the effect on the sleep cycle,
- impact on hormonal balance without increasing prolactin.
This content is for educational purposes only. It is not a recommendation for human use. The substance is intended for laboratory research only.
What is Ipamorelin?
Ipamorelin is a pentalanide peptide from the GHRP (growth hormone releasing peptides) group. Compared to other secretagogues, it is unique in that it specifically stimulates growth hormone secretion without a concomitant increase in cortisol or prolactin. Its selectivity makes it an interesting candidate in scientific research related to hormonal balance, regeneration and metabolism.
How does Ipamorelin work?
Ipamorelin acts on ghrelin receptors (GHS-R) in the pituitary gland, where it stimulates the natural secretion of growth hormone. In preclinical studies, its effect was selective - it did not affect the HPA axis (hypothalamic-pituitary-adrenal), which means that it did not cause an increase in stress hormones. The mechanism of action involves the activation of signaling pathways related to cell renewal, metabolism and anabolic processes.
Researched effects and interesting facts
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GH stimulation: increasing growth hormone levels without affecting cortisol
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Muscle protection: maintaining muscle mass during caloric deprivation
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Tissue regeneration: faster healing of muscles and soft tissues
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Sleep quality: observed effect on deepening and prolonging sleep
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Hormonal balance: minimal activation of ACTH or prolactin axes
Dosage in studies
The values listed are derived solely from research studies and are not intended for real-world use outside of a laboratory environment.
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Dose: 200-500 μg/kg per day
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Form: subcutaneous (sc)
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Frequency: 1–2 times a day
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Duration: 14 – 28 days depending on the destination
Possible side effects
- Transient irritation at the injection site
- Mild fatigue or drowsiness
- Rarely, swelling or water retention
- No increase in cortisol or prolactin in preclinical models
Resources
- Møller, N. et al. (2003). "Ipamorelin stimulates GH without affecting ACTH or cortisol." J Clin Endocrinol Metab
- Jasper, M. et al. (2004). "The effect of ipamorelin on growth hormone release." Peptides
- van den Berghe, G. et al. (2001). "Neuroendocrine dysfunction in critically ill patients." Clin Endocrinol
This article is for informational purposes only. It does not constitute a recommendation or solicitation for use. The information provided is a summary of existing scientific literature and is for educational purposes only.
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