5-Amino-1MQ is a small molecule that is being studied for its ability to inhibit the NNMT enzyme, thereby potentially affecting cellular metabolism, energy balance, and adipose tissue metabolism.
Concentration (test)
Unspecified
Packaging
Glass bottle with sterile cap
Storage
2–8 °C, away from light
Molecular formula
C7H10N4O
Molecular weight
166.18 g mol⁻¹
IUPAC name
1-methylquinolinium-5-amine
Other names
5-Amino-1-methylquinolinium
In laboratory studies, 5-Amino-1MQ has been linked to research in areas such as:
- loss of adipose tissue and inhibition of NNMT,
- increase in cellular energy expenditure,
- affecting the metabolism of NAD⁺ and sirtuins,
- support of regeneration and mitochondrial activity,
- supporting research into obesity and insulin resistance.
This content is for educational purposes only. It is not a recommendation for human use. The substance is intended for laboratory research only.
What is 5-Amino-1MQ
5-Amino-1MQ is a methylquinoline derivative that is being studied in the laboratory primarily as an inhibitor of the enzyme NNMT (nicotinamide N-methyltransferase). This enzyme plays a role in cellular metabolism and its increased activity has been observed in connection with obesity, metabolic disorders, aging and cancer cells.
Scientific studies suggest that blocking NNMT may increase NAD⁺ levels, which affects mitochondrial function, sirtuin expression, and overall cellular metabolic activity.
How 5-Amino-1MQ works
The effects of 5-Amino-1MQ lie in the inhibition of NNMT, an enzyme that reduces NAD⁺ levels by methylating nicotinamide. Inhibition of this enzyme can lead to increased NAD⁺ availability, which activates mitochondrial pathways, promotes fat oxidation, and improves cellular metabolism.
At the same time, the expression of genes involved in lipolysis and energy balance is affected, leading to a reduction in adipose tissue accumulation in preclinical models.
Effects studied
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Fat reduction: Proven loss of adipose tissue while preserving muscle mass in animal studies.
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Energy metabolism: Increased energy expenditure and fat oxidation in mitochondria.
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Cellular rejuvenation: Potential increase in NAD⁺ levels and activation of sirtuins – enzymes associated with longevity.
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Metabolic Disorders Research: Obesity, Insulin Resistance, and Related Inflammatory Processes.
Dosage in studies
The values listed are derived solely from research studies and are not intended for real-world use outside of a laboratory environment.
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Dosage: 10 – 25 mg daily
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Form of submission: subcutaneously or intramuscularly
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Frequency: 1× daily
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Duration: 2 – 6 weeks depending on the research objective
This product is not approved for human use. The data is for research and informational purposes only.
Possible side effects
- Injection site irritation
- Mild fatigue or temporary loss of appetite
- Rarely nausea or increased sweating
Resources
- Pissios, P. et al. (2017). Inhibition of NNMT promotes metabolic health
- Ulanovskaya, OA et al. (2013). NNMT promotes epigenetic remodeling in cancer
- Yoshino, J. et al. (2011). NAD+ intermediates and sirtuin biology
This article is for informational purposes only. It does not constitute a recommendation or solicitation for use. The information provided is a summary of existing scientific literature and is for educational purposes only.
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