Trans-ISRIB 25 mg – 60 capsules
research-grade
small-molecule capsules
supplied in a sealed bottle. Trans-ISRIB is the trans-isomer of ISRIB (Integrated Stress Response Inhibitor), a
potent small molecule studied as an inhibitor of the PERK–eIF2α phosphorylation pathway and a tool compound for
dissecting integrated stress response (ISR) signaling in cellular and central nervous system research models.
Research Use Only:
All products are intended exclusively for laboratory and scientific research. Not for human or veterinary use.
Purity
High-purity research grade
Content
25 mg Trans-ISRIB per capsule
Total count
60 capsules (total 1,500 mg per bottle)
Storage
Store at room temperature, protect from light, keep desiccated
Molecular formula
C22H24Cl2N4O4
Molecular weight
~495.36 g·mol⁻¹
IUPAC name
N,N'-(Azanediylbis(4,1-phenylene))bis(2-(4-chlorophenoxy)acetamide)
Research Overview
Trans-ISRIB is the active trans-isomer of the Integrated Stress Response Inhibitor (ISRIB), used in experimental
systems as a potent inhibitor of the cellular integrated stress response. In preclinical literature it is
characterized as acting downstream of PERK-mediated eIF2α phosphorylation to modulate eIF2B-dependent translation
control. Laboratory models employ Trans-ISRIB to study how selective interference with ISR signaling influences
protein synthesis, neuronal function and adaptation to cellular stress in central nervous system and systemic
stress paradigms.
Primary Research Areas
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Integrated stress response (ISR) signaling:
used as a tool compound to investigate how pharmacological inhibition of ISR signaling alters the PERK–eIF2α–eIF2B
axis, global protein synthesis and selective translation of stress-responsive mRNAs in cellular stress models.
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PERK–eIF2α phosphorylation and translation control:
applied in in vitro systems to study downstream consequences of PERK activation, eIF2α phosphorylation and
restoration of translation initiation, including effects on proteostasis markers and stress-adaptation pathways.
-
Memory and cognitive function models:
incorporated into preclinical paradigms that examine how modulation of ISR signaling influences learning,
memory consolidation and retrieval, synaptic efficacy and hippocampus-dependent tasks under controlled
laboratory conditions.
-
Traumatic brain injury (TBI) and CNS injury research:
used in experimental models of traumatic brain injury and related CNS insults to probe how ISR pathway
modulation affects neuronal survival, circuit function and recovery-associated endpoints.
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Neurodegeneration and synaptic plasticity:
evaluated in models of neurodegenerative processes and synaptic plasticity, where chronic or excessive ISR
activation is investigated as a mechanistic contributor to altered neuronal resilience, connectivity and
network performance.
