TAK-653 (Osavampator) 2 mg – 60 research tablets
research-grade small-molecule
compound in tablet form
supplied in a sealed bottle. Studied as a selective positive allosteric modulator (PAM) of AMPA receptors in central nervous system research models.
Research Use Only:
All products are intended exclusively for laboratory and scientific research. Not for human or veterinary use.
Purity
High-purity research grade
Content
2 mg TAK-653 (Osavampator) per tablet
Total count
60 tablets (total 120 mg TAK-653 per bottle)
Components / Contents
TAK-653 (Osavampator) as the active research compound
Storage
Store at room temperature, protect from light, keep desiccated
Molecular formula
C20H21N3O3S
Molecular weight
~399.47 g·mol⁻¹
IUPAC name
1-[4-(2-methanesulfonylphenyl)phenyl]-3-tricyclo[3.3.1.1³,⁷]decan-1-ylurea
Research Overview
TAK-653, also known as Osavampator, is a small-molecule research compound developed as a highly selective positive allosteric modulator (PAM) of the AMPA subtype of ionotropic glutamate receptors. In experimental models, TAK-653 enhances glutamatergic signaling by potentiating AMPA receptor responses without directly acting as a full agonist, and is studied in preclinical and clinical research exploring synaptic plasticity, mood regulation and central nervous system function.
Primary Research Areas
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AMPA receptor modulation:
Investigated as a selective AMPA receptor PAM, supporting studies on glutamatergic transmission, receptor desensitization and mechanisms that may underlie rapid changes in synaptic efficacy in CNS models.
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Mood and depression research:
Evaluated in experimental models and clinical research programs focused on major depressive disorder and mood regulation, where AMPA receptor potentiation is studied as a glutamate-based strategy distinct from classic monoaminergic approaches.
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Cognitive function and memory:
Used in laboratory studies investigating learning, working memory and long-term potentiation, where modulation of AMPA receptors is examined in the context of synaptic plasticity and information processing in cortical and hippocampal circuits.
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Synaptic plasticity and network dynamics:
Included in research on activity-dependent remodeling of excitatory synapses, changes in excitatory–inhibitory balance and network-level responses to AMPA receptor potentiation across different CNS regions.
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Neuroprotection and functional recovery:
Explored in preclinical models assessing how controlled enhancement of AMPA receptor activity may influence neuronal resilience, recovery after functional impairment and downstream pathways linked to neurotrophic signaling.
