O-304 (ATX) 100 mg – 30 capsules
research-grade
Autotaxin (ATX) inhibitor in capsule form
supplied in a sealed bottle. This synthetic small molecule is studied as a potent and selective inhibitor of Autotaxin (ENPP2), the key enzyme responsible for extracellular lysophosphatidic acid (LPA) production in experimental models.
Research Use Only:
All products are intended exclusively for laboratory and scientific research. Not for human or veterinary use.
Purity
High-purity research grade
Content
100 mg O-304 per capsule
Total count
30 capsules (total 3,000 mg per bottle)
Storage
Store at room temperature, protect from light, keep desiccated
Molecular formula
C25H23F3N2O5S
Molecular weight
~536.5 g·mol⁻¹
IUPAC name
3-[[4-[5-[3,5-dichloro-4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]-5-(hydroxymethyl)-2-oxazolidinone
Research Overview
O-304 is a synthetic small molecule inhibitor of Autotaxin (ATX), also known as ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2). ATX catalyzes the extracellular production of lysophosphatidic acid (LPA), a bioactive lipid mediator involved in cell proliferation, migration, survival, inflammation and fibrosis. In experimental in vitro and in vivo models, O-304 is used to investigate how selective ATX inhibition and subsequent LPA reduction affect pathological remodeling processes and disease-relevant signaling pathways.
Primary Research Areas
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Autotaxin (ATX/ENPP2) enzyme inhibition:
used to study potent and selective inhibition of Autotaxin activity and its downstream impact on LPA signaling in biochemical and cell-based assays.
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Lysophosphatidic acid (LPA) pathway modulation:
applied in research examining how reduced LPA production influences GPCR-mediated signaling, cell motility, survival and tissue remodeling in experimental systems.
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Fibrosis models:
investigated in preclinical models of fibrotic disease, including liver and lung fibrosis, where ATX–LPA signaling is implicated in excessive extracellular matrix deposition and chronic tissue injury.
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Inflammatory signaling and immune modulation:
used in studies focusing on inflammatory pathways, immune-cell trafficking and cytokine networks influenced by LPA and ATX activity in vitro and in vivo.
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Cancer proliferation and migration:
explored in oncology-oriented models where aberrant ATX–LPA signaling contributes to tumor cell proliferation, survival, invasion and metastasis in controlled laboratory settings.
