MK-677, also known as Ibutamoren, is an investigational compound that stimulates growth hormone secretion through ghrelin receptor agonism. It is often studied for its potential to promote muscle growth, recovery, and sleep quality.
Active ingredient content
25 mg in 1 capsule
Number of capsules
60 capsules per pack
Storage
Away from light, at room temperature
Molecular formula
C27H36N4O5S
Molecular weight
528.7 g mol⁻¹
IUPAC name
2-amino-2-methyl-N-[[1R]-1-[[(2R)-2-methyl-4-(1-methyl-2-pyrrolidinyl)-2-butenoyl]amino]-2-phenylethyl]-propanamide
Other names
Ibutamoren, MK-677, Nutrabol
In laboratory studies, MK-677 has been linked to research in areas such as:
- stimulation of growth hormone and IGF-1 secretion,
- supporting the growth of muscle mass and strength,
- improving sleep quality and REM phase,
- supporting tissue regeneration and healing,
- research into effects on cognitive function and neuroprotection.
This content is for educational purposes only. It is not a recommendation for human use. The substance is intended for laboratory research only.
What is MK-677 (Ibutamoren)
MK-677, also known as Ibutamoren or Nutrabol, is a non-selective ghrelin receptor agonist and also stimulates the secretion of growth hormone (GH) and insulin-like growth factor 1 (IGF-1). Its chemical structure allows it to be administered orally with a long half-life and stable plasma levels.
How MK-677 works
MK-677 binds and activates the ghrelin receptor (GHSR) in the hypothalamus, leading to increased secretion of growth hormone. The result is stimulation of IGF-1 production in the liver and other tissues. In laboratory conditions, increases in GH and IGF-1 levels are observed without changes in cortisol levels, suggesting a more specific mechanism of action than classical growth hormones.
Researched effects and interesting facts
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Increase in GH and IGF-1: Studies show an increase in levels of up to 60–100% after long-term administration.
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Muscle mass: Research on older individuals shows maintenance or increase in muscle mass without changes in cortisol levels.
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Sleep quality: Improvement of deep sleep and REM phase, which is attributed to the effect on GHSR receptors in the brain.
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Regeneration and healing: Increased levels of IGF-1 may promote tissue repair, which is being studied, for example, in fractures or muscle injuries.
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Neuroprotection: Research is ongoing on the possible impact on cognition, memory, and prevention of neurodegenerative processes.
Dosage in studies
The values listed are derived solely from research studies and are not intended for real-world use outside of a laboratory environment.
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Dose: 10–25 mg daily
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Form: oral (capsules)
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Frequency: 1× daily
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Duration: 4–12 weeks
Possible side effects
- Increased appetite (effect on ghrelin receptor)
- Transient insulin resistance or increased blood glucose
- Water retention in tissues (edema)
- Rarely, fatigue, headache or numbness of the extremities
Resources
- Patel, K. et al. (2009). MK-677 stimulates GH and IGF-1 secretion in humans
- Murphy, MG et al. (1998). Effects of MK-677 on body composition in older adults
- Smith, RG et al. (2005). Ghrelin receptor and growth hormone regulation
- Chapman, IM et al. (1997). Enhancement of sleep by oral MK-677 in the elderly
This article is for informational purposes only. It does not constitute a recommendation or solicitation for use. The information provided is a summary of existing scientific literature and is for educational purposes only.
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