KY-19382 5 mg/ml – solution 30 ml
research-grade
small-molecule solution
supplied in a 30 ml glass bottle. KY-19382 is a synthetic indirubin-derived compound studied as a dual
modulator of the Wnt/β-catenin signaling pathway, described in the literature as inhibiting GSK3β activity and
interfering with the CXXC5–DVL interaction in experimental models investigating bone growth, cartilage
biology, metabolic regulation and hair-follicle regeneration.
Research Use Only:
All products are intended exclusively for laboratory and scientific research. Not for human or veterinary use.
Purity
High-purity research grade
Form
Clear research solution
Content
5 mg KY-19382 per 1 ml; 30 ml per bottle (total 150 mg KY-19382 per bottle)
Packaging
30 ml glass bottle with sterile closure
Storage
Store at 2–8 °C; protect from light.
Molecular formula
C17H11Cl2N3O2
Molecular weight
360.19 g·mol⁻¹
IUPAC name
2H-indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro
Research Overview
KY-19382 is a synthetic indirubin-derived small molecule used as a tool compound in studies of Wnt/β-catenin
signaling. In preclinical work it has been characterized as a dual modulator that can inhibit GSK3β activity and
interfere with the CXXC5–DVL interaction, leading to enhanced Wnt/β-catenin pathway activity in selected
experimental systems. Laboratory research employs KY-19382 in cell and tissue models focused on bone and
cartilage growth, hair-follicle biology, metabolic regulation and other Wnt-dependent processes under strictly
controlled conditions.
Primary Research Areas
-
Wnt/β-catenin pathway modulation:
used in in vitro and in vivo models to study how dual modulation of GSK3β activity and the CXXC5–DVL interface
impacts β-catenin stabilization, nuclear translocation and transcriptional activation of Wnt target genes in
development and regeneration research.
-
Bone growth and cartilage / chondrogenesis models:
applied in studies of growth plate biology, chondrocyte proliferation and differentiation, and longitudinal
bone growth, where altered Wnt/β-catenin signaling is examined in the context of skeletal development and
age-related growth plate senescence.
-
Hair follicle and skin regeneration research:
incorporated into experimental systems investigating hair-follicle cycling, hair shaft elongation and dermal
regeneration, including models where Wnt/β-catenin signaling activators are evaluated under metabolic or
hyperglycemic stress conditions.
-
Metabolic and endocrine signaling models:
used as a probe compound in studies exploring how modulation of Wnt/β-catenin signaling intersects with
pathways relevant to metabolic homeostasis, glucose handling and adipocyte or hepatocyte biology in
preclinical settings.
-
Wnt-dependent disease and oncology research:
evaluated in cell and tissue models of Wnt-related pathologies, including fibrosis and selected tumor systems,
where dysregulated Wnt/β-catenin activity is a key mechanistic focus of laboratory investigation.
