BAM-15 50 mg research-grade capsules supplied in a sealed bottle with 60 units. BAM-15 is a mitochondrial protonophore uncoupler studied in experimental models of energy expenditure, fat oxidation and metabolic regulation.

Research Overview

BAM-15 is a small-molecule mitochondrial protonophore uncoupler investigated for its ability to dissociate electron transport from ATP synthesis without depolarizing the plasma membrane. In experimental in vitro and in vivo models, BAM-15 has been used to probe mitochondrial bioenergetics, nutrient oxidation, body-weight regulation and cellular responses to metabolic and inflammatory stressors.

Primary Research Areas

• Mitochondrial uncoupling & bioenergetics: used to investigate protonophore-driven uncoupling of oxidative phosphorylation, mitochondrial membrane potential and oxygen consumption rates in cell and tissue models.
• Energy expenditure & obesity models: applied in rodent studies examining diet-induced obesity, changes in whole-body energy expenditure and adiposity under conditions of mitochondrial uncoupling.
• Glucose metabolism & insulin sensitivity: explored in metabolic research focused on insulin resistance, glycemic control and hepatic lipid handling in high-fat-diet models.
• Inflammation, sepsis & organ-injury models: used in preclinical work on acute kidney injury, sepsis-like conditions and inflammatory signaling, where mitochondrial function and ROS production are key readouts.
• Oncology & cellular stress pathways: investigated in cancer and cellular stress models to study how mitochondrial uncoupling influences cell survival, proliferation and stress-adaptation mechanisms.